“Meet the neighbors: A universal technology for probing RNA-interactions and RNA-scaffolded subcellular compartments in situ”
|Zoom Webinar Link: https://washington.zoom.us/j/94084786076|
Assistant Professor in the Department of Pharmacology
Dr. Shechner is an Assistant Professor in the Department of Pharmacology at UW. His laboratory seeks to understand how RNA molecules help to organize subcellular compartmentalization, and how these cryptic architectural functions are perturbed throughout various human pathologies. Towards this goal, the Shechner lab specializes in developing new chemical biology and genomics tools for probing and manipulating RNA functions in situ. Their flagship project has been the development of O-MAP, is a nearly universal method for elucidating the proteins, transcripts, and genomic loci surrounding nearly any RNA of interest, and in nearly any biological setting, with exceptional precision. With this powerful new approach in hand, they now aim to decipher the molecular mechanisms by which RNAs scaffold subcellular structures like nucleoli and Barr bodies, and how nascent transcripts modulate and functionalize nuclear architecture. Deciphering these longstanding, previously intractable questions will reveal fundamental principles driving subcellular architecture, and facilitate the discovery of novel biomarkers and therapeutic targets in heart disease, developmental disorders, and cancer.