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Science in Medicine Lecture with Kayode Ojo, Ph.D.
March 10 @ 11:00 am - 12:00 pm
“A case for new “brakes” against Giardiasis runs”
Giardiasis is a gastrointestinal illness characterized by bouts of greasy watery diarrhea, stomach cramps, and nausea. Giardia lamblia is the causative agent of giardiasis. Global studies estimate 280 million symptomatic cases per year. It is one of the most common waterborne diseases worldwide. Clinical giardiasis treatment relies on antimicrobial chemotherapy but up to 20% of cases are resistant to available drugs. Developing inexpensive alternatives should be a public health priority. In this talk, Dr. Ojo will discuss the use of structure-based design of compounds that target essential giardia enzymes to identify therapeutic leads. Discussion will include preclinical studies using new animal infection models and empirical approaches to guide medicinal chemistry optimization which improves therapeutic properties.