“Enlisting glial cells for self-repair in the nervous system: it’s never too late to change their fate.”
Professor, Department of Biological Structure
The neural retina of mammals, like most of the rest of the central nervous system, does not regenerate new neurons after they are lost through damage or disease. The regenerative ability of non-mammalian vertebrates, like fish and amphibians, to replace lost neurons is remarkable, and lessons learned over the last 20 years have revealed some of the mechanisms underlying this potential. This knowledge has recently been applied to mammals to develop methods to stimulate regeneration in mice. In this lecture, I will highlight the progress in this area, and propose a roadmap for how the clinical implementation of regenerative strategies could be applicable to many different human retinal diseases.