SIM: New Investigator Lecture with Smita Yadav, Ph.D.
November 18 @ 11:00 am - 12:00 pm
“Mapping the Neuronal Kinome: The Role of Aberrant Kinase Signaling in Neurodevelopmental Disorders”
From the genesis of a neuron to its functional integration into synaptic networks, every aspect of
neuronal development is regulated by protein kinases. Kinases are highly druggable enzymes
that catalyze the addition of phosphate groups to their substrates with high spatial and temporal
specificity. Although kinases are increasingly implicated in the pathophysiology of several
neurological diseases, current understanding of how the human kinome controls brain
development is limited. We are investigating how aberrant kinase signaling contributes to
neurodevelopmental diseases, including autism spectrum disorder. Our work will provide
insights into the neurobiology of disease states and potentially lead to novel drug targets.
Dr. Smita Yadav is an Assistant Professor in the Department of Pharmacology and a faculty
member at the Institute of Stem Cell and Regenerative Medicine at the University of
Washington. Dr. Yadav earned her doctoral degree at Carnegie Mellon University and completed
her postdoctoral training at University of California San Francisco. Her research focuses on
neuronal development and the role of kinase dysfunction in autism spectrum disorders. Her
research has been funded by the NIH Pathway to Independence Award, the Brain and Behavior
Foundation, and the National Institute of Mental Health.