The Rigor, Reproducibility, and Transparency (RRT) Seminar Series is a series in collaboration with the Fred Hutch Cancer Center presented by faculty from each of the several ongoing training grants at Fred Hutch and UW. Presenters include faculty from training grants at the Fred Hutch and the UW. The series is in response to NIH-mandated RRT training for trainees on training grants, F awards, and K awards. Lectures focus on a detailed discussion of common or emerging methodologies with the aim of describing strengths, limitations, and pitfalls so those employing or interpreting the data gain a realistic sense of what can and cannot be learned.

The October seminar will feature Manu Setty, PhD, Assistant Professor, Basic Sciences Division, Herbold Computational Biology Program, Public Health Sciences Division, Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutchinson Cancer Center

“Rigor and reproducibility in computational research”

Computational research carries its specific reproducibility risks: methods can overfit to the datasets they were developed on, results can depend on undocumented parameter choices, and analysis code often cannot be rerun months later. In this seminar, I will describe practices that can be used to maintain rigor, robustness, and reproducibility across computational research, from method development to data interpretation. These include validating methods on simulated and independent datasets, benchmarking against existing approaches, testing sensitivity to parameters and data quality, and building analysis pipelines with version-controlled, openly shared code. I will illustrate these practices with case studies from our work on single-cell and spatial genomics.

Fred Hutch trainees: To receive RRT seminar credit, you must attend the Zoom seminar live (or watch the recording within 30 days of the live seminar) and then fill out this survey stating three things you learned.  Click here to find out more about the Rigor, Reproducibility and Transparency Seminar Series.

UW trainees: To receive RRT seminar credit, you must attend the Zoom seminar live (or watch the recording within 30 days of the live seminar) and then fill out this survey stating three things you learned. Click here to visit the UW webpage to learn​​ more about the seminar series, including a recording of the seminar in the “Seminar Schedule” section for that seminar.

Zoom Information